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Belly Fat Puts Women at Risk for Osteoporosis

CHICAGO—For years, it was believed that obese women were at lower risk for developing , and that excess body fat actually protected against bone loss. However, a study presented today at the annual meeting of the Radiological Society of North America (RSNA) found that having too much internal may, in fact, have a damaging effect on bone health.

RSNA Fat Osteoporosis

CT scan of the abdomen through the level of L4 in an obese women (age: 34 years, body mass index [BMI] 30 kg/m2), showing high visceral adipose tissue (VAT: 103 cm2). Image and caption courtesy of the RSNA.

“We know that obesity is a major public health problem,” said the study’s lead author, Miriam A. Bredella, M.D., a radiologist at Massachusetts General Hospital and assistant professor of radiology at Harvard Medical School in Boston. “Now we know that abdominal obesity needs to be included as a risk factor for osteoporosis and bone loss.”

According to the Centers for Disease Control and Prevention (CDC), approximately 72 million adults in the U.S. are considered obese. The CDC defines obesity as having a body mass index (BMI) of 30 or more. Obesity is associated with many health problems including cardiovascular diseases, diabetes, high cholesterol, asthma, sleep apnea, and joint diseases. Yet despite all the health issues, it was commonly accepted that women with increased body weight were at a lower risk for bone loss.

But not all body fat is the same. Subcutaneous fat lies just below the skin, and visceral or intra-abdominal fat is located deep under the muscle tissue in the abdominal cavity. Genetics, diet, and exercise are all contributors to the level of visceral fat that is stored in the body. Excess visceral fat is considered particularly dangerous, because in previous studies it has been associated with an increased risk for heart disease.

Abdominal fat and osteoporosis

RSNA Fat Osteoporosis

Corresponding 1H-MRS spectrum of the fourth lumbar vertebral body showing prominent lipid peak (bone marrow lipid to water ratio: 1.1), indicating high bone-marrow fat content. Image and caption courtesy of the RSNA.

Dr. Bredella and colleagues set out to evaluate the abdominal subcutaneous, visceral, and total fat, as well as bone marrow fat and bone mineral density, in 50 premenopausal women with a mean BMI of 30. Each woman underwent an MR spectroscopy (MRS) exam to evaluate the bone marrow fat of the L4, the fourth vertebra in the lumbar section of the spine. Then, the bone mineral density of the L4 was assessed using quantitative computed tomography (QCT), which measures bone mass and is used to assess bone loss.

The imaging revealed that women with more visceral fat had increased bone marrow fat and decreased bone mineral density. However, there was no significant correlation between either subcutaneous fat or total fat and bone marrow fat or bone mineral density.

“Our results showed that having a lot of belly fat is more detrimental to bone health than having more superficial fat or fat around the hips,” Dr. Bredella said.

According to the National Women’s Health Information Center, 10 million people in the U.S. have osteoporosis and 18 million more have low bone mass, placing them at risk for the disease.

“It is important for the public to be aware that excess belly fat is a risk factor for bone loss, as well as heart disease and diabetes,” Dr. Bredella said. Although bone loss is more common in women, the research team is currently conducting a study to determine whether belly fat is also a risk factor for bone loss in men.

The takeaway items from the study are:

  • Excess visceral fat, located deep in the abdomen, may increase a woman’s risk of osteoporosis.
  • Approximately 72 million people in the U.S. are considered obese.
  • Approximately 10 million people in the U.S. have osteoporosis, and 18 million more are at risk.

The study coauthors are: Martin Torriani, M.D.; Reza Hosseini Ghomi, M.S.E.; Bijoy Thomas, M.D.; Anne Klibanski, M.D.; and Karen Miller, M.D.

Belly Fat Puts Women at Risk for Osteoporosis RSNA Fat Osteoporosis

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