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Acupuncture Changes Brain’s Perception and Processing of Pain

CHICAGO—Using functional magnetic resonance imaging (), researchers have captured pictures of the brain while patients experienced a pain stimulus—with and without —to determine ’s effect on how the brain processes pain. Results of the study, which the researchers say suggest the effectiveness of , were presented today at the annual meeting of the Radiological Society of North America (RSNA).


Functional magnetic resonance (fMR) images showing brain activity during electrical pain stimulation at the left ankle. Parts of the so-called “pain matrix” are activated; in these images the left insula is activated. Image and caption courtesy of the RSNA.

“Until now, the role of acupuncture in the perception and processing of pain has been controversial,” said lead researcher Nina Theysohn, M.D., from the department of diagnostic and interventional radiology and neuroradiology at University Hospital in Essen, Germany. “Functional MRI gives us the opportunity to directly observe areas of the brain that are activated during pain perception and see the variances that occur with acupuncture.” fMRI measures tiny metabolic changes that take place in an active part of the brain, while a patient performs a task or is exposed to a specific external stimulus.

In the study, conducted in close collaboration with the department of complementary and integrative medicine at the University of Duisburg-Essen, 18 healthy volunteers underwent fMRI while an electrical pain stimulus was attached to the left ankle.

Acupuncture, fMRI and Pain.

Acupuncture needles were then placed at three areas on the right side of their body: Between the toes, below the knee, and near the thumb. With the needles in place, fMRI was repeated while electrical currents were directed at the left ankle. The researchers then compared the images and data obtained from the fMRI sessions with no acupuncture with those of the fMRI sessions with acupuncture. “Activation of brain areas involved in pain perception was significantly reduced or modulated under acupuncture,” Dr. Theysohn said.

Specifically, fMRI revealed significant activation in the contralateral supplementary motor area, somatosensory cortex, precuneus bilateral insula, and ipsilateral somatomotor cortex during electrical pain stimulation without acupuncture. During acupuncture, activation in most of these pain-processing areas of the brain was significantly reduced. According to Dr. Theysohn, in addition to the assumed specific effects on the pain signal, acupuncture also affected brain activation in areas governing the patients’ expectations of pain, similar to a placebo analgesic response.

The anterior insula, for example, plays a role in transforming pain sensation to cognition and represents a subjective component of pain sensation. The reduction in activation of the primary somatosensory cortex and the insula during acupuncture indicates an acupuncture-induced modulation of the sensory encoding of the painful stimulus. “Acupuncture is supposed to act through at least two mechanisms—nonspecific expectancy-based effects and specific modulation of the incoming pain signal,” Dr. Theysohn said. “Our findings support that both these nonspecific and specific mechanisms exist, suggesting that acupuncture can help relieve pain.”

The takeaway items from this study are:

  • Acupuncture reduces activation in several brain areas involved in the perception and processing of pain.
  • According to fMRI results, acupuncture affects the incoming pain signal to the brain.
  • Acupuncture also sparks a placebo-like analgesic response in the brain.

The study coauthors are: Kyung-Eun Choi, M.Sc.; Elke Gizewski, M.D., Ph.D.; Thomas Rampp, M.D.; Gustav Dobos, M.D., Ph.D.; Michael Forsting, M.D., Ph.D.; and Frauke Musial, Ph.D.

Acupuncture Changes Brain’s Perception and Processing of Pain RSNA Acupuncture


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